Non-Invasive Bladder Cancer is a bladder cancer that hasn’t spread into the muscle of your bladder and is kept inside the lining of the bladder. The vast majority of bladder cancers, over 70%, are found at this stage. This is also sometimes called ‘superficial bladder cancer’ or ‘early stage bladder cancer’.
Bladder cancer is, however, the cancer that has the highest recurrence rate. This will mean that you are likely to have a lifetime relationship with investigations and treatments as your medical team works to remove the tumours and then works hard again to help prevent them coming back. You will have regular check ups with a cystoscopy to see if the bladder cancer has come back and your treatment will begin again if it does.
In cases of non-invasive bladder cancer, it is usually possible to remove the cancer cells while leaving the rest of the bladder intact. This is done using a surgical technique called transurethral resection (TURBT). This is sometimes followed by a course of chemotherapy, which is placed directly into the bladder to prevent the cancer returning. This method of using chemotherapy directly into the bladder reduces the risk of some side-effects, such as hair loss.
If your bladder cancer is the lower risk type it is possible that you will not need any more treatment than the TURBT and the initial chemotherapy installation. You will be monitored for a year to make sure it doesn’t come back and the current guidelines suggest that you can be discharged at this point but do watch out for any symptoms.
Your treatment will also usually include a medication known as BCG (Bacillus Calmette-Guerin) which is injected into your bladder. BCG has been found to encourage the immune system to destroy any remaining cancerous cells. The immune system is the body’s natural defence against infection and illness. The BCG treatment is commonly carried out over a number of weeks in outpatient appointments. If you are about to start treatment with BCG we would recommend that you join our Confidential Forum to speak to others who have had this treatment. They can share their experiences of the treatment and their tips for dealing with the realities of the treatment course.
Your medical team will aim to remove all the cancer cells by the TURBT procedure (explained in more detail below), but they will further refine their treatment recommendations as the procedure progresses, and once they have the additional results from any biopsy. They will recommend treatment based on limiting the risk of the cancer coming back or spreading further than the lining of your bladder.
The risk is calculated using a series of factors, including:
Quite simply, the exact treatment you will be offered depends on your medical team’s view on the risk of your cancer returning.
Sometimes, with a non=invasive bladder cancer that is very high risk, you might be asked to consider having your bladder removed as the best way of dealing with your diagnosis. This might sound very frightening but it is a common treatment for those of us who have been diagnosed with invasive bladder cancer. If this is suggested to you please do have a look at our section on invasive bladder cancer that covers this surgery and our Patient Choices download.
The standard surgical treatment for non-invasive bladder cancer is known as a transurethral resection of the bladder tumour (TURBT). In most cases, a TURBT can be performed at the same time as a biopsy. A TURBT is always carried out under general anaesthetic. The surgeon will use an instrument called a cystoscope to locate all of the visible tumours and will then cut them away from the lining of the bladder.
Once the tumour(s) have been removed, any bleeding can be stopped using a mild electric current to seal the wound. If you experience significant bleeding, a thin, flexible tube called a catheter may be inserted into your urethra and passed up into your bladder. The catheter will be used to drain away any blood and debris from your bladder, and it may need to be kept in place for several days.
Most people are able to leave hospital within 48 hours of having a TURBT and are able to resume normal physical activities within two weeks.
After surgery, you might be given one or more courses of chemotherapy. You will have your first course when you have recovered from the effects of the general anaesthetic. A type of chemotherapy called intravesical chemotherapy is used. It involves placing a liquid solution of chemotherapy medication directly into your bladder using a catheter. The solution will be kept in your bladder for about an hour before being drained away.
Some residue of the chemotherapy medication may be left in your urine, so be careful not to splash yourself or the toilet seat with urine, because it could irritate your skin. After having a wee, wash your genitals, and your hands, with soap and water.
The advantage of intravesical chemotherapy is that because the medication is placed inside your bladder (rather than being injected into your blood), you will not experience the side effects that are most commonly associated with chemotherapy, such as feeling sick, tiredness and hair loss. The most common side effect of intravesical chemotherapy is irritation and inflammation of the bladder lining. This can sometimes make you feel like you need to wee a lot, or make weeing painful. Don’t worry, these side effects should pass within a few days.
If your cancer is low risk, you shouldn’t need any more treatment. However, if your cancer is medium or high risk, you will be given additional courses of chemotherapy, usually once a week for 6 weeks. If you have sex, it is important that you use a condom while you are having intravesical chemotherapy, because the medication used can temporarily affect the quality of a man’s sperm and a woman’s eggs, potentially increasing the risk of birth defects. If you’re at all worried about sex and your relationship during your treatment, have a chat with your specialist nurse who can give you some one-to-one advice.
The BCG vaccine is used to treat the higher-risk cases of non-invasive bladder cancer to reduce the risk of the cancer returning.
The BCG vaccine was originally used to treat tuberculosis (TB), but it has also proved to be an good treatment for bladder cancer. Exactly how it works is still unclear. It appears to stimulate the immune system to target and destroy any remaining cancer cells. The vaccine is given in the same way as intravesical chemotherapy – a liquidised version is passed directly into your bladder. The vaccine will be left in your bladder for 2 hours before being drained away.
Following treatment with BCG, you will also need to be careful about not splashing yourself or the toilet seat with wee.
The current advice is for an induction treatment in the first year after diagnosis and then either 1 or 2 more years of maintenance treatments whilst having regular check-ups.
The induction course is normally weekly treatments over a 6-week period. Maintenance therapy of up to another 2 years of treatment may be recommended after the induction course, which will involve further doses of the BCG vaccine every 6 months, with a series of 3-weekly doses.
The common side effects of BCG treatment include:
You should inform your medical team if the side effects become particularly troublesome because other treatments are available to help.
BCG treatment can sometimes be uncomfortable or painful. Some people are lucky and sail through the treatment, whilst others have quite a difficult time during the process.
Look after yourself!
BCG treatment affects people in many different ways, from “No problems at all ” to “That was hell and I needed every painkiller available.”
Our Confidential Forum is a great place to get extra advice and tips on dealing with BCG treatment.
It is important to use a condom during sex if either you or your partner is having BCG treatment. Do talk to your specialist nurse to get advice on this.
Bladder cancer has the highest recurrence rate of any cancer, so it is possible that you will have a lifetime relationship with this cancer. You will soon settle down into the routine of checks and possible additional treatments. Sometimes it is good to talk to others in the same situation, so do visit our Confidential Forum.
Sometimes, despite the best medical intervention, non-invasive bladder cancer can still progress to invasive bladder cancer. If this is happening to you, find out more about the treatments and options you now face on our page about invasive bladder cancer.
Remember that the majority of people diagnosed with bladder cancer do beat it. You can find out more about life after bladder cancer in our surviving bladder cancer section.
Don’t forget that we have some great downloadable information to help you.
We’ve done everything we can to make all the information on this site as accurate as possible. Whilst we have had support from a small team of medical professionals advisors to review the general medical content of this site, please remember, that only YOUR medical team can give YOU specific advice about YOUR symptoms or illness. We encourage you to discuss any potential options with them.